@Halyo_Alex Here is what Brandon has to say on the matter.
Maru Nui
What happens when you burn a Hemalurgic spike?
Brandon Sanderson
Burning a Hemalurgic spike would have the effect of splicing your spiritual DNA to that of the person's that is in the spike, which would have some very strange consequences.
And we will get an answer at some point
Questioner
Will there ever be an Allomancer trying to burn a Hemalurgically charged metal?
Brandon Sanderson
Yes.
This possibly might be an indication of the fundamental differences of Metalmind vs spike charge
Questioner
If someone had a Hemalurgic spike and they burned aluminum, would the negation of-- am I going to get RAFO'd?
Brandon Sanderson
You're asking if it would destroy the Hemalurgic power? Burning aluminum at that point would not destroy the Hemalurgic power. It would pull the Investiture through whatever you're doing. It would blank your power, but it wouldn't destroy you being an Allomancer with the spike...
I actually considered this in building it and that would be too easy a way to remove Inquisitors, particularly if there were dissension between them.
With most Metalminds, they just hold a well of power that was stored and tapped, much different than a Hemalurgic charge which is more like a spiritual genetic graft. What makes it confusing though is Nicrosil Feruchemy which seems to store the part of the Spiritweb that has the ability into their Nicrosilmind which is a fair bit different than any other Metalmind we know about with the possible exception of Copperminds. It seems to be an almost non lethal version of Hemalurgy. We'll probably just have to wait until we know more about Nicrosil Feruchemy to understand what distinguishes it from Hemalurgy
Edit:wow my quote formatting freaked out there. I hope I got it fixed enough to still make sense