I'm thinking that his Oathstone will either turn out to be able to bind him to the holder's will, which would feed into his despair. I'm imagining a scene where Szeth would be ordered to do something he couldn't bring himself to do, or maybe just one murder too many, and he goes to either leave, or kill the person who holds his Oathstone.
This would either leave him with despair as his only motivation, as he abandoned his religion in ignoring the order.
Or, it could renew his faith in his religion, if the Oathstone is a religious item, which could lead to redemption (albeit through death. I don't see Szeth living happily ever after).