Probably don't need to include, but huge spoilers for RoW and Mistborn:
This feels like a very general question and more than likely it has been answered and I just didn't look hard enough for the corresponding thread, but in case it has not been:
What are the prerequisites for holding a shard?
Obviously humans can take them, as we saw with Taravangian and Sazed. This leads to the assumption that all sentients can take them (so a parshendi could in theory hold a shard). If sentience is the only prerequisite, then could nightblood hold a shard? Ignoring its other special properties such as feeding off investiture and cutting in the spiritual realm, is its sentience sufficient to allow it hold a shard? We always see people 'take' shards through some physical action. Does this imply that physical agency is required? If so this would disqualify nightblood.
I expect I have misinterpreted nightblood's sentience in some way, but even if so my first question remains: what are the prerequisites to take/hold a shard?
Edit: After some more reading, it appears that nightblood is a sort of artificial spren. This makes sense seeing how it was created to mimic shardblades, and leads to another question which seems a bit easier to answer: could a spren hold a shard? This has (sort of) been answered in WoB, but in short no because its investiture would just combine with the shard it tried to pick up. So are the differences between nightblood and spren sufficient to allow it to do so?
Also, the coppermind does state that Connection to the shard is the major prerequisite. Clearly Nightblood can form a Connection (consider its bonds with those have wielded it in the past), but I am unsure if it could form a sufficient Connection with a specific shard to actually become its vessel.