Much more, you have to know "what kind of Spike is needed to remove the specific powers".. With the Metallic Arts is quite easy, but we don't know how use it with other Magic Systems.
But a Skilled Hemalurgist may kill quite anyone with a not-lethal damage. Remember that while performing Hemalurgy, the Physical Damage isn't "the Killing blow" (The organ arrange itself to avoid damage) but the soul ripping effect.
One Hemalurgist with enough precision and skill, may kill someone creating a Strenght Spike from the Victim's foot (for example ). If the victim hasn't any kind of Soul-Healing he will probably die.