Hmm good point! I wonder would happen if you tried to awaken a dead mistborn, I highly doubt the resulting lifeless would be be able to use allomancy (though as far a sheer awesomeness goes, that would be be pretty cool, zombies that can riot fear? Pretty sweet). But yeah I guess investitures do not always mesh well, so it might not be so simple as saying a single command.
As for the human thing, I thought that the point of making things human shaped, and using organic materials and whatnot was just to make it seem more like it was once alive, or at least making the association between it and a living thing stronger. In a sense the shardblade was once alive, and so maybe its memory of having lived would make it organic enough to lower the number of breaths. I mean the lifeless squirrel vasher awoke only took a single breath if I remember correctly. In any case a once living shardblade seems closer to "life" to me than a sword shaped hunk of metal that has never actually been anywhere close to living before.
I think what would matter more would be how much awakening would be able to affect the cognitive and spiritual realm, as a spren's presence in the physical realm is not really that strong. I mean it would not have to replace honor/cultivation's investiture at all, just shift the nature of what it thinks its bond is. (I believe the bond is "found" in the spiritual realm, seems the most likely place at least, as a hemalurgic spike can steal the bond according to WoB).