Cheesy name: Wiseacre
Primary power: Proximity competence. Is mentally as proficient in any given subject as anybody who is within visual range or earshot. This includes somebody communicating from afar via a mobile or even an Epic Power, and works in either direction -- if you can see him *or* if he can see you. Even if you don't actually see/hear him, what matters is that you could. If not practiced, the proficiency will leave when the subject does.
Does not specifically gain muscle density or superpowers or the like, nor does it confer specific factual knowledge. For instance, Wiseacre might gain mathematical skill around a mathematician, and even some esoteric knowledge about mathematicians and the history of mathematics. However, Wiseacre does not have an equal proficiency at remembering what you had for lunch yesterday as you do. That's specific knowledge, rather than proficiency. This said, if your lunch was broadcast on reality TV, and an avid fan of the show was watching, then he may very well know. Also, people may generally be considered proficient in their own autobiography, so Wiseacre will have some general knowledge of your history.
Secondary power: Practicing in the presence of a proficient person makes the proficiency more "permanent" at an extremely accelerated rate -- including factual knowledge.
Weakness: Sensory deprivation. This is a two-way (or many-way) street though. It's not enough that Wiseacre can't see or hear you -- you and everybody else can't see or hear Wiseacre.
That might seem like it's really just not activating his main ability, rather than an actual weakness, but he actually loses his "practiced" proficiencies as well. In fact, under these conditions, he remembers relatively little (not nothing) since Calamity, since memory is really tied with the mental state in which the memory was formed, and much of that mental state doesn't actually belong to WiseAcre in the first place.
Evil manifestation:
He was tired of being ignored and thought of as less than he truly was, so now he inflicts the same curse upon others. People with specialized skills are kept under his employ performing menial tasks, and specifically kept away from their areas of competence. People without specialized skills are experimented on until they die. His compound has constant, massive surveillance.
Note the nature of his ability isn't really a prime invincibility, but it makes him difficult to assassinate on purpose. He is proficient at assassination around assassins; proficient at Epic biographies whenever a lorist is in contact; can take a pretty good guess at any approaching Epic's weakness; and is as good a shot as anybody trying to take him out.
He's more likely to have trouble in a random act of violence.
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Came up with another while doing the first.
Cheesy name: The Surgeon
Primary power: Shapeshift others. Size can change, mental faculties may or may not change at the surgeon's discretion. Your full mental faculties remain intact -- even if you are transformed into an insensate object like a statue. You are, however, influenced by your new biochemistry. After turning into a frog you will instinctively want to eat flies. And you'll start to be attracted to frogs. If you are transformed into a human of the opposite gender, you will *probably* (though not certainly) find your attractions shift over time. You will age at a rate relative to the lifespan of the thing you were transformed into, so you could be aged forward a lot if you were a fly, and you could age not at all if you were an inanimate object. You can also be explicitly shapeshifted back to a younger or older age.
This shift is permanent unless The Surgeon himself dismisses the shapeshifting. Even if the weakness is invoked, previous shapeshifting remains in place. If the Surgeon is killed, victims are trapped forever (similar to how Newcago didn't turn back from steel when Steelheart died).
To shapeshift you for the first time, you must be touched.
Secondary power: Can remove previous shapeshifts at will, regardless of range. That said, somebody who has been transformed into a statue for 10 years is pretty much guaranteed to be insane at release time. This can be selective: a man who is made younger and given horns can have the horns removed without re-aging him. But new transformations can't be applied without being nearby: somebody who was 80, then de-aged to physically 20, then turned into a mayfly and released for two weeks, will physically be about 80 again when the mayfly transformation is removed. If the de-aging is removed, he would die imminently.
Weakness: Powers do not work in the presence of something that fools The Surgeon into thinking it is something else. Basically, something wearing a convincing disguise.
Note that the fact that the weakness triggers can actually cause The Surgeon to detect the disguise and get his powers back for a second attempt. So you need something that is still convincing upon close examination, or possibly several decoys and a lot of confusion. Certain Epics would be very good at this.
Evil manifestation: Takes hostages in family groups, turning them into small animals, or their legs to stone, or whatever amuses him, to get others to serve him. All of his hostages spend time back in their old body, but never the whole family at once. This means people serve him to keep their family safe, but nobody dares try to kill him, because it will condemn their family to forever be transformed.