As far as I can tell, Stormlight is a lot more efficient than Breath.
If you look at the comparison between Shardblades and Nightblood which has been going on for a while around here you can see some very interesting points.
Brandon himself said that on Roshar Nightblood is practically a Shardblade but stronger (cant find the link to the source right now, sorry), this is something I thought of even before I read him say it, since when Vasher used Nightblood at the end of Warbreaker, he could slice through anything, just like a Shardblade.
Another interesting point is that at the end of WoR Syl tells Kaladin that the Honorblades feed on their wielders Stormlight and that it takes a LOT of it. Just like Nightblood consumes Breath.
This leads me to believe that Nightblood is more like an Honorblade than a Shardblade, but that's beside the point.
If Brandon said Nightblood is actually an Honorblade I think we can assume that an Honorblade and Nightblood would consume the same amount of investiture.
BUT
if you look at the scene where Vasher draws Nightblood, he goes through thousands of breaths in a matter of minutes, if not less. Compared to Szeth that seems a bit extreme doesn't it? I mean, Szeth's blade took a big chunk of his Stormlight but its not like merely holding it caused him to be drained of all light in a matter of minutes.
My conclusion is that Stormlight is just more efficient. I would guess the last Highstorm would be able to hold Vasher up until the end of the weeping easily.
P.S.
First post on these forums, be gentle XD