This game was competitive with me (Kelsier), @The WorldHopper Taynix (Vin) and @Emperor Comatose (Marsh). 

All of us started going for the Luthadel Rooftops mission track to get as much training as soon as possible. Marsh picked up Balance early on, but only used it like once several turns later. I got Maelstrom and Ruin, which made the other two start to team up against me. After an attack that did 14 damage, Marsh was dead, leaving just me and Vin. Vin used a lot of damage and healing cards, but I was able to use copper cards like Coppercloud and Hide (I think that's what it was called?) to block the damage. I survived with 1 health. I got him down to 6 on my next turn, and I thought I was dead for sure until it turned out that Vin could only do 4 damage that turn, and I had more than enough copper cards to block that. So, with 1 health, I was able to burn atium and steel and win the game.

It was 4 player Bios: Genesis, with me (red), @The WorldHopper Taynix (yellow), @Hoid the ShardBoy (green) and my non-Sharder non-Sanderfan brother (red). 

It took ages for anyone to get a bacterium. We went all the way to the start of the Proterozoic without a single one.

Eventually, the Hydrothermal Vents from turn 2 became @The WorldHopper Taynix's bacterium, and I got one two from a refugium I can't remember.

Some time later, my brother got a bacteria too, and @The WorldHopper Taynix was very quickly knocked down to a single biont, and every time he bought something, he immediately lost it. My bacteria fared far better, and the parasites were fighting over who got to parasitise me

Mine did eventually lose a lot of cubes, and @The WorldHopper Taynix's finally succumb to bad rolls. That left only my brother's bacteria alive, and it had every biont in it, and @The WorldHopper Taynix for some reason was very altruistic and helped turn it into seaweed on the final turn.

The final VP scoring was 9 (my brother), 8 (@The WorldHopper Taynix), 7 (me), and 5 (@Hoid the ShardBoy)

I know, a really dry game. For some reason, all my 4P Genesis games are.

I guess the presence of more people really makes the dice want to cooperate less.

I wasn't using the actual solo rules, because those had become too easy on both Earth and Mars (I intend to tackle Venus another time). I was instead playing multi-hand, so I was controlling all four players using default Earth rules.

Really early on, Laurentia, the craton with Player Orange (hydroskeletal, so mollusks, annelids, etc), collided with Baltica, the craton with Player Green (cytoskeletal, plants and fungi). Immediately a green-cube arms race began, with both species trying to outcompete the other. At the area of interchange, the oranges found themselves at the top of the food chain. Some evolved flower-like structures that only plants have on Earth, relying on the real plants (green) for pollination. At some point Green also got Jealousy, the first emotion of the game. Green also amassed enough blue cubes to raft over to Siberia, and ended up battling Player Black (exoskeletal, arthropods). The very next turn, Siberia collided into Laurentia and Baltica, forming a supercontinent. It was a huge arms race that followed.

Whilst all this was happening, Player White (endoskeletal, vertabrates) chilled on Gondwana, not interacting with any of the other players 

Finding themselves unable to match Green and Orange in green cubes, Black decided to specialise in carnivory, especially in forested areas, by getting a lot of red cubes. Black also got Jealously at this time. At this point, though both Green and Black had the cube count to raft over to Gondwana, they couldn't because their entire supercontient was as far south as possible, whilst Gondwana was on the equator.

The supercontinent's ecology faced even more turmoil when Green evolved venom. Black, who'd almost exclusively preyed on Green, would almost certainly face extinction if they didn't do something. They were lucky and was able to purchase mutations with venom too, counteracting that of Green, and now were the undisputed apex predators of the supercontinent since the Orange predators died out. 

Meanwhile, White was gathering enough cards with the right emotions, and on Turn 6, the last turn of Era I, White got Language, with one Jealousy and two Curiosity. Normally, the game is supposed to end at the end of Era II, or III if it's the Long Game, but I decided to end it here. In a future Bios: Origins game (with actual solo rules), I would play as White and see how far I could get. It would be really interesting to see how their society would develop, as they'd have to cross the oceans before they could find anything to domesticate. 

Something really interesting was that no speciation ever happened this game. It did kind of make sense, since if Green, Black or Orange ever speciated the new species would immediately be driven to extinction, and White simply had no reason to do so. Now, if I simply wasn't treating this like a paleontological simulation and actually tried to win as each player, White would probably have speciated to get some extra VPs or something, but yeah.

That was my Megafauna game!

One really good thing that happened to me was that as one of the starting ten cards, I got Aquifer Pumping, which was arguably one of the best cards in the game. It's a blue card and costs 18 to play, and it's action is that you can spend 8 MC to get an ocean.

Extremely cheap oceans.

I also invested a lot in early game heat, energy and plant production, thanks to a really good starting hand, so I was doing a lot of terraforming, though not as much as the other two early on, who used a lot of red cards to get some fast terraforming. Both of them were ahead of me TR-wise basically the entire game.

At generation 8, @The WorldHopper Taynix showed up, and so he joined as Saturn Systems, and to compensate somewhat we started him with 33 TR (my brother, who had the most at the time, had 30 then). 

Temperature filled up really fast as both me and other-non-Sharder had a lot of heat production, and oceans followed quickly. I claimed Gardener, since I had a lot of greenery, and funded Thermalist. My brother claimed Terraformer and funded Miner, since he had like 30 steel that he barely used and no one else had more than 5. Other-non-Sharder claimed Mayor. Oxygen took a bit but we eventually got there on generation 11, the fastest TM game (generation wise) I'd ever played.

In the end, if you discounted placement VPs, my brother would've won with me close behind, other-non-Sharder trailing and @The WorldHopper Taynix far behind. Instead, since me and other-non-Sharder were the only ones who really tried to get placement VPs, I ended up winning with 64 VPs and other-non-Sharder coming second at 62, and my brother at 56 and @The WorldHopper Taynix somewhere in 40s, which was to be expected since he'd had a massive disadvantage.

'Twas a fun game.

My leader was Princess Irulan, and I randomly drew two rivals, which turned out to be Staban Tuek and Princess Irulan (yes, I'm playing against myself)

Both had a high Swordmaster value, which was good since I hadn't played Mentat.

Really early on, I started using my Signet Ring ability to cut down my deck. For whatever reason, I never got very much persuasion, so I bought very few cards, and I trashed most of those for spice.

For the first two conflicts, I didn't commit any troops at all as I sprinted down the Fremen influence to get Sandworms. After I did, I started sandworming a lot, and used by plethora of spice for some Highliners early on. Sandworm doubling was really useful.

Eventually though, the Irulan bot became too strong with like Maker Hooks and a lot of troops, as well as 3 storming alliances, so lost a lot of the late-game ones. Both bots got Swordmaster early on, and I did too eventually, which is actually something I don't do much. I usually go for High Council first, which I didn't get at all this game.

By the end of the game, my deck was only 5 cards. I got 9 VPs, Staban got 6, and the Irulan bot got 10. So yes, I lost to myself.

But it was close, and I did better than I expected to on my first Mentat difficulty game.